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Texas A&M Prof. Discovers New Therapy for Refractory Epilepsy

HOUSTON – Dr. Samba Reddy, professor at Texas A&M University College of Medicine has identified a new approach to blocking frequent epilepsy seizures.

Epilepsy is a chronic neurological disorder characterized by unpredictable seizures that affect more than 65 million people in the world. Seizures can usually be controlled with antiepileptic medications, but as many as two out of five patients with epilepsy have seizures that are refractory. This occurs when seizures are frequent enough that it interferes with a person’s life, and cannot be controlled with current medications.

Prof. Reddy has been working tirelessly for over two decades to find solutions to gain control of epilepsy.

His recent work, co-authored by his graduate student Shu-Hui Chuang, was published in the Journal of Pharmacology and Experimental Therapeutics. They used an arithmetic technique called isobolographic analysis to select the best combination regimen of two drugs in order to achieve the highest efficacy, and found that the positive interaction between two neurosteroids (brexanolone and ganaxolone) and two antiepileptic medications (tiagabine and midazolam) is so significant that it could help treat refractory epilepsy.

Prof. Samba Reddy is from Warangal, Telangana in India. He is known as a reputed scientist, author, and community service volunteer and for his pioneering work on pharmaceuticals. Besides brain research, he has been very actively promoting public awareness about the Coronavirus pandemic. His selfless services in combating the COVID-19 have been recognized by many associations, institutions, and scientific organizations worldwide.

Texas A&M University



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